APCs	antigen-presenting cells
APOBEC	apolipoprotein-B mRNA editing enzyme catalytic polypeptide-like
Bcl-xL	B cell lymphoma-extra large
bTMB	plasma-based tumor mutational burden
cCSCs	circulating cancer stem-like cells
CPS	combined positive score
CTCs	circulating tumor cells
ctDNA	circulating tumor DNA
CTLA-4	cytotoxic T lymphocyte antigen 4
dMMR	mismatch repair deficiency
EBV	Epstein-Barr virus
EpCAM	Epithelial cell adhesion molecule
FDA	Food and Drug Administration
GEP	gene expression profile
HNSCC	head and neck squamous cell carcinoma
HPV	human papillomavirus
ICIs	immune checkpoint inhibitors
IFN	interferon
IS	immunoscore
LAG-3	lymphocyte-activating gene 3
NIH	National Institutes of Health
Mb	megabase
MSI	microsatellite instability
MSI-H	high microsatellite instability
NK	natural killer
OR	odds ratio
OS	overall survival
PD-1	programmed cell death protein-1
PD-L1	programmed death ligand-1
PFS	progression-free survival
R/M HNSCC	recurrent and metastatic HNSCC
SCC	Squamous cell carcinoma
SOC	standard of care
TCGA	The Cancer Genome Atlas
TIGIT	T cell immunoreceptor with Ig and ITIM domains
TIM-3	T cell immunoglobulin and mucin domain-containing protein 3
TMB	tumor mutational burden
TME	tumor microenvironment
TPS	tumor proportion score
Tregs	regulatory T cells