Table 1.
Characteristics of fenbendazole (FEN)-loaded micelles.
| Polymer Amount Used (mg) | FEN Amount Used (mg) | Particle Size (nm) | Poly-Dispersity Index (PDI) | Zeta-Potential (mV) | Encapsulation Efficiency (EE %) | Drug Loading (DL %) |
|---|---|---|---|---|---|---|
| mPEO-b-PCL 100 mg | 1.0 | 96.8 ± 3.8 | 0.14 ± 0.01 | −0.4 ± 0.1 | 24.7 ± 2.0 | 0.2 ± 0.02 |
| mPEG-b-PLA 100 mg | 1.0 | 347.7 ± 40.4 | 0.26 ± 0.04 | −9.5 ± 2.1 | 56.8 ± 2.8 | 0.6 ± 0.03 |
| Pluronic F127® 100 mg | 1.0 | 1566.5 ± 157.8 | 0.23 ± 0.09 | −4.6 ± 0.1 | N.D.a | N.D.a |
| Soluplus® 50 mg |
1.0 | 65.4 ± 2.3 | 0.11 ± 0.03 | −2.4 ± 0.2 | 58.3 ± 3.1 | 0.6 ± 0.03 |
| Soluplus® 100 mg |
1.0 | 68.3 ± 0.6 | 0.01 ± 0.02 | −2.3 ± 0.2 | 85.3 ± 2.9 | 0.8 ± 0.03 |
a N.D., not detectable due to precipitation. (n = 3; mean ± SD).