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. 2020 Oct 21;12(10):1000. doi: 10.3390/pharmaceutics12101000

Table 2.

Pharmacokinetic parameters of fenbendazole (FEN) after intravenous injection of FEN-loaded Soluplus® micelles and FEN dissolved in 25% Cremophor EL®/EtOH solution.

Parameter FEN Solution FEN-Loaded Soluplus® Micelle
AUC a (min·µg·mL−1) 156 ± 2.6 234 ± 56.9
C0 b (µg·mL−1) 2.2 ± 0.3 5.1 ± 0.2
CLt c (mL·kg−1·min) 12.8 ± 0.2 9.0 ± 1.9
Vd d (mL·kg−1) 906 ± 112 393 ± 12.9

a AUC, area under the curve; b C0, plasma concentration at time zero; c CLt, total clearance; d Vd, volume of distribution.