Table 4.
CI values of CS with OA and ART in the A2780ZD0473R cell line where drugs were added in equipotent ratios based on IC50 values.
| CI Values at | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug | Sequence (h) | Molar Ratio | ED50 | ED75 | ED90 | Dm | m | r |
| CS | N/A | N/A | N/A | 11.35 | 0.83 | 0.98 | ||
| OA | N/A | N/A | N/A | 29.43 | 0.43 | 0.96 | ||
| CS + OA | 0/0 | 1:1.3 | 0.58 | 0.61 | 0.86 | 3.55 | 0.61 | 0.99 |
| CS + OA | 0/4 | 0.81 | 0.56 | 0.52 | 5.00 | 0.80 | 0.99 | |
| CS + OA | 4/0 | 0.80 | 0.71 | 0.74 | 5.53 | 0.73 | 0.99 | |
| ART | N/A | N/A | N/A | 17.19 | 0.57 | 0.99 | ||
| CS + ART | 0/0 | 1:4.35 | 0.71 | 0.80 | 0.95 | 1.46 | 0.56 | 1.00 |
| CS + ART | 0/4 | 0.82 | 0.91 | 1.36 | 1.71 | 0.53 | 0.99 | |
| CS + ART | 4/0 | 0.82 | 0.85 | 1.09 | 1.89 | 0.58 | 1.00 | |
Dm: medium effect dose, m: exponent defining shape of the dose effect curve, r: reliability coefficient.