Table 5.
* Platinum Accumulation | ||||
---|---|---|---|---|
A2780 | A2780cisR | |||
DRUG | Value | Fold Change | Value | Fold Change |
CS | 0.15 ± 0.01 | - | 0.27 ± 0.02 | - |
CS + ART (0/0 h) | 0.65 ± 0.04 | 4.33 | 2.29 ± 0.20 | 8.48 |
CS + ART (0/4 h) | 0.91 ± 0.06 | 6.06 | 0.75 ± 0.04 | 2.77 |
CS + ART (4/0 h) | 0.22 ± 0.02 | 1.46 | 1.22 ± 0.09 | 4.51 |
CS + OA (0/0 h) | 2.22 ± 0.08 | 14.8 | 0.91 ± 0.08 | 3.33 |
CS + OA (0/4 h) | 0.27 ± 0.01 | 1.8 | 0.50 ± 0.02 | 1.85 |
CS + OA (4/0 h) | 0.22 ± 0.01 | 1.46 | 1.14 ± 0.11 | 4.22 |
* Expressed as: nmol Pt per 5 × 106 cells.