Table 6.
Platinum–DNA-binding levels of CS alone and in combinations with ART and OA.
| * Platinum–DNA Binding Level | ||||
|---|---|---|---|---|
| A2780 | A2780cisR | |||
| DRUG | Value | Fold Change | Value | Fold Change |
| CS | 6.08 ± 0.57 | - | 3.66 ± 0.49 | - |
| CS + ART (0/0 h) | 9.24 ± 0.64 | 1.52 | 3.70 ± 0.33 | 1.01 |
| CS + ART (0/4 h) | 8.26 ± 0.78 | 1.36 | 8.67 ± 0.59 | 2.37 |
| CS + ART (4/0 h) | 3.22 ± 0.49 | 0.53 | 4.60 ± 0.11 | 1.26 |
| CS + OA (0/0 h) | 4.13 ± 0.28 | 0.68 | 5.12 ± 0.43 | 1.40 |
| CS + OA (0/4 h) | 1.66 ± 0.11 | 0.27 | 4.43 ± 0.29 | 1.21 |
| CS + OA (4/0 h) | 4.71 ± 0.36 | 0.77 | 7.85 ± 0.73 | 2.14 |
* Expressed as: nmol Pt per mg of DNA.