Table 9.
Characteristics of proteins that have undergone differential expressions in A2780 and A2780cisR cell lines following treatment with selected drug combinations using A2780cisR cell line as reference.
| Mach ID | Protein ID | Full Name | Mascot Search Results | Location | References |
|---|---|---|---|---|---|
| 8 | ATP5H O75947 |
ATP synthase subunit d, mitochondrial | Mass: 18480 Mascot score: 128 Coverage: 57% pI: 5.21 MS: 11 MSMS: 3 |
Mitochondrion | [15] http://www.matrixscience.com |
| 9 | RAN P62826 |
GTP-binding nuclear protein Ran | Mass: 24408 Mascot score: 132 Coverage: 39% pI: 7.01 MS: 11 MSMS:1 |
Nucleus | [15] http://www.matrixscience.com |
| 12 | PSA7 O14818 |
Proteasome subunit alpha type-7 | Mass: 27870 Mascot score: 85 Coverage: 39% pI: 8.60 MS: 10 MSMS: 1 |
Cytoplasm | [15] http://www.matrixscience.com |
| 13 | TPI P60174 |
Triosephosphate isomerase | Mass: 30772 Mascot score: 340 Coverage: 49% pI: 5.65 MS: 20 MSMS:3 |
[15] http://www.matrixscience.com |
|
| 16 | VDAC1 P21796 |
Voltage-dependent anion-selective channel protein 1 | Mass: 30754 Mascot score: 368 Coverage: 51% pI: 8.62 MS: 12 MSMS: 3 |
Mitochondrion outer membrane | [15] http://www.matrixscience.com |
| 18 | hnRNPA2/B1 P22626 |
Heterogeneous nuclear ribonucleoproteins A2/B1 | Mass: 37407 Mascot score: 258 Coverage: 48% pI: 8.97 MS: 21 MSMS: 6 |
Nucleus, nucleoplasm | [15] http://www.matrixscience.com |
| 22 | PGK1 P00558 |
Phosphoglycerate kinase 1 | Mass: 44586 Mascot score: 145 Coverage: 48% pI: 8.30 MS: 22 MSMS: 1 |
Cytoplasm | [15] http://www.matrixscience.com |
| 25 | GOT1 P17174 |
Glutamate oxaloacetate transaminase 1 | Mass: 46219 Mascot score: 331 Coverage: 66% pI: 6.52 MS: 27 MSMS: 6 |
Cytoplasm | [15] http://www.matrixscience.com |
| 30 | EF1A1 P68104 |
Elongation factor 1-alpha 1 | Mass: 50109 Mascot score: 135 Coverage: 25% PI: 9.10 MS: 13 MSMS: 2 |
Cytoplasm | [15] http://www.matrixscience.com |
| 32 | ACTG P63261 |
Actin, cytoplasmic 2 | Mass: 41766 Mascot score: 598 Coverage: 55% pI: 5.31 MS:26 MSMS:5 |
Cytoplasm, cytoskeleton | [15] http://www.matrixscience.com |
| 41 | KPYM P14618 |
Pyruvate kinase PKM | Mass: 57900 Mascot score: 188 Coverage: 33% pI: 7.96 MS: 23 MSMS: 3 |
Cytoplasm. | [15] http://www.matrixscience.com |
| 44 | P4HB P07237 |
Prolyl 4-hydroxylase subunit beta | Mass: 57081 Mascot score: 433 Coverage: 50% PI: 4.76 MS: 29 MSMS: 6 |
Endoplasmic reticulum lumen | [15] http://www.matrixscience.com |
| 57 | APG2 P34932 |
Shock 70-related protein APG-2 | Mass: 94271 Mascot score: 125 Coverage: 25% pI: 5.11 MS: 22 MSMS:3 |
Cytoplasm (Probable) | [15] http://www.matrixscience.com |
| 58 | VINC P18206 |
Vinculin | Mass: 123722 Mascot score: 226 Coverage: 34% pI: 5.50 MS: 40 MSMS:4 |
Cytoplasm, cytoskeleton | [15] http://www.matrixscience.com |
| 63 | EF2 P13639 |
Elongation factor 2 | Mass: 95277 Mascot score: 425 Coverage: 27% pI: 6.41 MS: 39 MSMS:7 |
Cytoplasm | [15] http://www.matrixscience.com |
| 69 | CLIC1 O00299 |
Chloride intracellular channel protein 1 | Mass: 26906 Mascot score: 158 Coverage: 47% pI: 5.09 MS: 11 MSMS: 3 |
Nucleus | [15] http://www.matrixscience.com |
Accession number, protein ID, names and Mass, MSMS, coverage and protein score were obtained from APAF (http://www.proteome.org.au/). Theoretical isoelectric point (pI), subcellular location mass spectrum and matched peptides were obtained from Mascot database (http://www.matrixscience.com), Swiss-Prot database (http://www.uniprot.org/) [15]. Protein scores from Mascot database (http://www.matrixscience.com) through APAF (http://www.proteome.org.au/).