Table 2.

The role of non-coding RNAs regulated by MYC involved in cancer aggressiveness and metastasis. A brief summary of non-coding RNAs controlled by MYC, the processes they influence, and the respective targets/signaling pathways mediating these processes.

	Processes	Target/Signaling Pathways	References
microRNAs activated by Myc
miR-17-92 cluster:
miR-18a miR-19	Angiogenesis	CTGF ↓ TSP-1 ↓	[11,106,107,109]
miR-105	Metabolic rewiring Angiogenesis Metastasis, EMT	MIX1 ↓ ZO-1 ↓ ZO-1 ↓ RAP2C ↑	[104,136,137,235,236]
miR-9	Angiogenesis Metastasis, EMT	HIF-1α/VEGF axis E-Cadherin ↓	[103,218]
microRNAs suppressed by Myc
miR-148a-3p	EMT	ERBB3/AKT2/MYC axis	[233]
miR-200	EMT	Zeb-1 ↑ Zeb-2 ↑	[108,231]
long non-coding RNAs activated by Myc
HOXC13-AS	Migration, invasion, EMT	MYC ↑	[237]
LIN28B	EMT	let-7 ↓ HMHA2 ↓ Snail ↑	[172,221,222,223,224]
HOTTIP	Migration, invasion, EMT Metastasis	MYC ↑ β-catenin ↑ Vimetin ↑ DKK1 ↓	[239,240,241]
LINC01433	Migration, EMT	Myc ↑ (via sponging miR-2116-3p)	[238]
BCYRN1	Metastasis	MMP-9 ↑ MMP-13 ↑	[242]