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. 2020 Oct 14;21(20):7597. doi: 10.3390/ijms21207597

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of Wnt and Notch pathways on TGF-β superfamily signaling to control the expression of targeted genes in osteoprogenitors and bone-forming cells [216,217,274,275,276,277]. APC: adenomatous polyposis coli; β-TrCP: β-transducin repeat-containing protein; CKIα: Casein kinase Iα; Dkk1: Dickkopf1; DVL: Disheveled; ENG: Endoglin; GSK3 β: Glycogen synthase kinase-3 β; LEF: Lymphoid enhancer-binding factor; LRP5/6: low-density-lipoprotein-related protein 5/6; NICD: Notch intracellular domain; TCF: T cell factor; and U: ubiquitination. The figure was created using Servier Medical Art. https://smart.servier.com.