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. 2020 Aug 13;598(19):4321–4338. doi: 10.1113/JP279961

Figure 3. Vitamin D does not inhibit low pH‐induced TRPV1 currents.

Figure 3

A and B, representative whole‐cell current recording (A) and grouped data (B) of macroscopic TRPV1 currents, using a paired pulse protocol (P2/P1), illustrating that 25OHD (100 nM) significantly inhibits TRPV1 currents induced by 1 µm capsaicin (P2/P1 ratios for capsaicin only and capsaicin+25OHD are 0.55 ± 0.06 and 0.27 ± 0.05, respectively, n = 6–8 cells). C, in contrast, 25OHD did not reduce TRPV1 currents induced by low pH (pH 5.5). D, the P2/P1 ratio for pH 5.5 and pH 5.5+25OHD = 0.46 ± 0.05 and 0.51 ± 0.07, respectively, n = 4–6 cells per group. E and F, 25OHD alone partially activates TRPV1 currents. F and G, application of 25OHD during the steady‐state phase of the pH 5.5‐induced current did not significantly TRPV1 activity (S2/S1 ratio). n = 4–6 cells per group. ** P < 0.01; NS, no significant difference. [Color figure can be viewed at wileyonlinelibrary.com]