Table 2.

Human TRPV1 residues that are predicted to interact with 25OHD

Ligand pose	First protomer	Second protomer
1	Phe522, Phe543, Leu547, Met581	Ile662, Leu665, Ala666, Ile669, Leu670
2	Phe543, Ala546, Leu547, Met581	Phe591, Leu665, Ala666, Ile669, Leu670
3	Phe522, Phe543, Leu547	Phe591, Ile662, Leu663, Ala666, Leu670,
4	Phe522, Phe543, Leu547	Phe591, Ile662, Leu663, Ala666, Leu670
5	Phe543, Ala546, Leu547, Met581	Phe591, Leu663, Leu665, Ala666, Ile669, Leu670

The top five poses of the 25OHD interactions with the lowest values of negative ΔG (free energy) are listed.