Nucleic acids landscape of platelets. Platelets harbor a diverse set of RNA species, most of which are inherited from megakaryocytes. Additionally, communications with surrounding cells might also influence RNA expression landscape. Transport of RNA from megakaryocytes to platelets is not well understood, however, is suggested to be—at least in part—mediated by RNA-binding proteins (RBPs). Pre-mRNA and pre-miRNA are processed by a functional spliceosome and by the presence of the cytoplasmic miRNA processing into translate mRNA and mature miRNA, respectively, which can be signal-dependent. Platelets may also host infectious virus particles and mediate dissemination of viruses in infected individuals. By secreting RNA and protein contents by platelet granules or microvesicles, platelets may regulate signaling pathways in various interacting cells, including tumor or endothelial cells.