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Valeric acid prevented rotenone mediated neuronal apoptosis by restoring mTOR pathway. Immunoblotting of midbrain samples with mTOR pathway (A) proteins and apoptotic markers (C). Blots for phosphor mTOR and p70S6K (B), Bax and Bcl-2 (D) mTOR were quantified using Image J and represented as fold of control. Values are expressed as mean ± SEM. a p < 0.05 compared to control, b p < 0.05 compared to rotenone treated group, c p < 0.05 compared to Rot+Val treated group.
