Figure 2.

Changes in the severity of depression during the treatment of patients (n = 4) diagnosed with bipolar disorder in the depressive phase by adding amantadine to the mood stabilizer. The severity of depression was assessed using the HDRS scale four times—before the start of treatment (week 0), after the week (week 1), after 2 weeks (week 2), and after three weeks of treatment (week 3). The asterisks mark the patients whose dose of amantadine was increased to 200 mg/day in the second week. * the patients whose dose of amantadine was increased to 200 mg/day in the second week.