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. 2020 Jul 24;598(19):4307–4320. doi: 10.1113/JP280120

Figure 4. Proinflammatory cytokines increased airway surface liquid pH and induce HCO3 − absorption or minimal HCO3 − flux.

Figure 4

1 of 6 cystic fibrosis (CF) donors was excluded from the IL‐13 analysis because of a high IL‐13‐induced paracellular HCO3 − conductance of 0.868 mS cm−2, Grubb's test α ≤ 0.01. Red circles represent HCO3 − data and black circles represent Cl− data, each for a single donor. A, paracellular PHCO3 reported in Table 2 and Table 3; two‐tailed paired Student's t test, P values shown. B, GHCO3 calculated using Eqn 6, paracellular GHCO3 increased due to increased apical [HCO3 −]; two‐tailed paired Student's t test, P values shown. C, paracellular HCO3 − flux calculated using Eqn 9 and Faraday's constant. Minimal HCO3 − secretion was reduced or absorptive with cytokine treatments; two‐tailed paired Student's t test, P values shown.