Table 2.

IL‐13 increases airway surface liquid pH of human cystic fibrosis airway epithelia, but does not alter paracellular ion permeabilities

	21 days vehicle (PBS)	21 days IL‐13	P value
Native airway surface liquid (ASL) experiments; n = 6
ASL pH †	6.58; [6.51, 6.63]	7.40; [7.20, 7.76]	<0.0001
22 mm NaCl dilution potential experiments; n = 6
GP (mS cm−2)	0.802 ± 0.355	0.755 ± 0.259	0.75
PCl/Na	0.73 ± 0.06	0.61 ± 0.16	0.06
PNa (x10−6 cm s−1)	6.87 ± 2.92	7.08 ± 1.70	0.49
PCl (x10−6 cm s−1)	5.11 ± 2.39	4.48 ± 2.19	0.15
22 mm NaHCO3 dilution potential experiments; n = 5 ‡
GP (mS cm−2)	0.664 ± 0.292	0.749 ± 0.158	0.51
PHCO3/Na	0.74 ± 0.07	0.61 ± 0.18	0.12
PNa (x10−6cm s−1)	5.44 ± 2.21	6.52 ± 1.57	0.41
PHCO3 (x10−6 cm s−1)	4.43 ± 2.14	4.61 ± 0.85	0.67
150 mm NaCl/KCl bi‐ionic potential experiments; n = 5 ‡
PK/Na	1.09 ± 0.08	1.11 ± 0.12	0.67

Data reported as means ± standard deviation

P values obtained using two‐tailed paired Student's t test

^†Statistical analyses, including mean and standard deviation, were performed using [H⁺]. For presentation, the [H⁺] were converted to pH, and hence the standard deviations are shown as intervals.

^‡Donor excluded from analysis; Grubb's test α ≤ 0.01