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. 2020 Oct 21;21(20):7788. doi: 10.3390/ijms21207788

Figure 6.

Figure 6

SST4 receptor activation decreases firing frequency of layer V pyramidal cells of the primary somatosensory cortex (S1). Representative voltage responses of interneurons (n = 7, (A)), layer II–IV pyramidal cells (n = 12, (C)), and layer V pyramidal cells (n = 10, (E)) of the somatosensory cortex upon step current injections (250 and –200 pA) under control conditions (black) and after bath application of 1 µM J-2156 (colored; (B,D,F,H)). Layer V pyramidal cells of Sstr4lacZ/lacZ mice not showing any response to J-2156 served as negative control (n = 12, (G)). Statistical analysis was performed by paired Student’s t-test on the firing frequency of corresponding cells upon 250 pA step current injections under control and J-2156 treated conditions. Paired Student’s t-test **: p = 0.003.