Figure 7.
SST4 receptor activation augments M-current in layer V pyramidal cells of the primary somatosensory cortex (S1). Representative current traces from interneurons (n = 6, (A)), somatosensory cortex layer II–IV pyramidal cells (n = 11, (B)), layer V pyramidal cells (n = 11, (C)), and elicited by the voltage protocol indicated at the top of each panel under control conditions (black) and after bath application of 1 µM J-2156 (colored). M-current was determined as the difference of the instantaneous current at the beginning of the current trace, and the steady current at the end of the current trace. Bottom side: statistics showing M-current amplitude of corresponding cells under control and J-2156 treated conditions. Paired Student’s t-test *: p = 0.016.