Table 2.

Genome-wide significant SNPs for each phenotype in either AES cohort or in meta-analysis.

SNP	CHR	BP	A1	A2	AES						AESES				Meta-analysis					N	Annotation	Distance	Gene Symbol	Gene Context
					pa	ORa	FRQb	pb	ORb	SEb	FRQ	p	OR	SE	pFixed_effect	OR	pwald	pcorrected	pstouffer
SSRI responders vs. non-responders
rs4884091	13	78,973,223	G	A	2.42 × 10−08	1.21	0.79	3.49 × 10−07	1.22	0.04	0.80	0.02	1.09	0.04	1.67 × 10−07	1.16	1.21 × 10−08	1.37 × 10−08	1.34 × 10−08	22225	ncRNA_intronic	0	RNF219-AS1	EDNRB---[]---POU4F1
SNRI responders vs. non-responders
rs4955665	3	169,355,019	T	C	3.13 × 10−04	1.19	0.59	2.64 × 10−04	1.21	0.05	0.60	1.21E-06	1.27	0.05	1.62 × 10−09	1.25	4.35 × 10−09	3.94 × 10−09	4.04 × 10−09	8119	intronic	0	MECOM	[MECOM]
NTRD vs. TRD
rs150245813	10	38,592,780	T	G	7.32 × 10−08	0.79	0.88	7.35 × 10−07	0.79	0.05	0.88	1.40E-03	0.81	0.07	8.07 × 10−09	0.80	8.88 × 10−10	4.22 × 10−10	4.08 × 10−10	29488	ncRNA_intronic	0	ENSG00000226113	ZNF37A---[]---LINC00999

AES Antidepressant Efficacy Survey, AESES Antidepressant Efficacy and Side Effects Survey, BP base-pair, CHR chromosome, FRQ frequency, NDRI norepinephrine-dopamine reuptake inhibitor, NTRD non-treatment-resistant depression, OR odds ratio, SE standard error, SNP single nucleotide polymorphism, SNRI serotonin-norepinephrine reuptake inhibitor, SSRI selective serotonin reuptake inhibitor, TRD treatment-resistant depression.

^awith overlapping samples between AES and AESES cohorts.

^bwithout overlapping samples between AES and AESES cohorts.

p_{Fixed_effect} was computed between the AES (without overlapping samples) and AESES cohorts using PLINK, while p_wald, p_corrected, and p_stouffer were computed between AES (with overlapping samples) and AESES cohorts using METACARPA.

Bold numbers indicate p < 5 × 10⁻⁸.