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. 2020 Oct 26;10:18217. doi: 10.1038/s41598-020-75062-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of mutSignatures Modules. Diagram summarizing the three modules of the mutSignatures framework. Module 1 is aimed at importing and preparing mutation data from VCF files or other sources. A DBGenome object is required for computing mutation types. Analytic parameters are set before running NMF. Module 2 is aimed at extracting mutational signatures by NMF, or computing signature activities via the fcnnls function. Module 3 includes functions for comparing mutational signatures and data visualization. A summary of Input/Output (I/O) objects is shown.