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. 2020 Oct 26;11:5406. doi: 10.1038/s41467-020-18961-0

Fig. 6. Nod2 functions independent of Rip2-signaling in T cells.

Fig. 6

a–b EAU was induced in WT and Rip2−/− mice. Data are combined from 3 independent experiments. For WT, n = 10 (10 and 19 day) and 24 (13 day). For Rip2−/−, n = 9 (10 day), 21 (13 day), 12 (19 day). a Clinical uveitis was evaluated weekly by fundoscopy; *p = 0.0320. b Representative fundus photographs 13 days post-immunization. c–d Rag1−/− mice were reconstituted with thymocytes from naïve WT or Rip2−/− mice and immunized with IRBP 8 days later. Data are combined from 2 independent experiments with n = 10 (WT recipients) and n = 18 (Rip2−/− recipients). c Clinical uveitis was evaluated by fundoscopy 28 days post-immunization; *p = 0.0074. d Representative fundus photographs are shown. Data are mean ± SEM (a) or box-whisker plots showing median, 25–75th percentile, and min–max range (with dots representing individual values) (c). Statistical differences between groups were calculated using two-tailed Mann–Whitney U test (a, c). Source data are provided as a Source Data file.