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. 2020 Oct 26;10:18215. doi: 10.1038/s41598-020-75209-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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APP23 mice show a better glucose tolerance than WT mice, but ADV APP23 mice are more vulnerable to SRD-induced glucose intolerance. Glucose tolerance can be moderately improved by chia seeds in ADV APP23 and age-matched WT mice. (a,b) Glucose tolerance of PRE (a) and ADV mice (b) represented by area under the curve in (mg/dl) × min in week 12 at the end of pretreatment. (c,d) Glucose tolerance of PRE (c) and ADV mice (d) represented by area under the curve in (mg/dl) × min in week 20 at the end of therapy. Each box represents the 25th to 75th percentile, the line represents the median, whiskers reach from minimum to maximum. An asterisk indicates significant differences between groups regardless of significance level (p < 0.05), according to nonparametric multiple contrast Tukey-type test. WT wild type control, APP23 transgenic mouse model, PRE pre-plaque stage, ADV advanced-plaque stage, CD control, SRD sucrose-rich, Chia chia seed supplementation.