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. 2020 Oct 26;10:18215. doi: 10.1038/s41598-020-75209-z

Figure 5.

Figure 5

ADV APP23 mice show slight SRD-induced insulin insensitivity and generally increased corticosterone levels compared to age-matched WT mice, the latter being moderately improved by chia seeds. (a,b) Fasting plasma insulin levels adjusted for BW [µg/l/g] of PRE (a) and ADV mice (b). (c,d) Fasting plasma corticosterone levels adjusted for BW [nmol/l/g] of PRE (c) and ADV mice (d). Each box represents the 25th to 75th percentile, the line represents the median, whiskers reach from minimum to maximum. An asterisk indicates significant differences between groups regardless of significance level (p < 0.05), according to nonparametric multiple contrast Tukey-type test. WT wild type control, APP23 transgenic mouse model, PRE pre-plaque stage, ADV advanced-plaque stage, CD control, SRD sucrose-rich, Chia chia seed supplementation, BW body weight.