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. 2020 Oct 26;10:18277. doi: 10.1038/s41598-020-75260-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Depicts individual’s clinical courses. Time from ICU-admission in days is displayed on the x-axis. Upward vertical movement indicates worsening of the clinical condition (up: intubation + positive pressure ventilation (PPV), requiring prone positioning, requiring sustained low efficiency dialysis (SLED), advanced organ support (ADVOS = dialysis + albumin-dialysis + CO2 removal) or extracorporeal membrane oxygenation (ECMO = oxygenation + CO2-removal). Downward vertical movement indicates reduced requirement of organ support, spontaneous breathing and discharge from ICU in good clinical condition.