Table 2.

Lipid and glucose profiles in mice with HFD and UTS-001 treatment.

Parameters	Chow-PBS	Chow-UTS-001 (0.6 mg)	Chow-UTS-001 (6 mg)	HFD-PBS	HFD-UTS-001 (0.6 mg)	HFD-UTS-001 (6 mg)
Serum TG (mg/mL)	0.94 ± 0.032	1.15 ± 0.05	1.06 ± 0.047	1.12 ± 0.047*	1.21 ± 0.062 **	1.19 ± 0.062 ***
Serum FFA (nM)	4.82 ± 0.21	4.74 ± 0.27	4.9 ± 0.25	5.49 ± 0.35	5.95 ± 0.48	4.8 ± 0.15
Liver Oil Red O staining (OD/mg of tissue)	0.0057 ± 0.00032	0.0066 ± 0.00059	0.00501 ± 0.00031	0.01898 ± 0.00321 ***	0.02489 ± 0.0016 ****	0.019 ± 0.00346 ****
Glucose (mM)	12.8 ± 1.2	12.9 ± 1.4	14.8 ± 0.3	17.5 ± 1.2 **	19.15 ± 0.9 ***	18.1 ± 1.1 **
Serum insulin (ng/mL)	0.399 ± 0.02	0.40 ± 0.04	0.409 ± 0.04	0.412 ± 0.02	0.399 ± 0.03	0.415 ± 0.03
HOMA-IR	0.22 ± 0.02	0.24 ± 0.03	0.27 ± 0.01	0.34 ± 0.02 ****	0.34 ± 0.01 ***	0.32 ± 0.02 ***

Data are expressed as mean ± S.E.M. and were analysed using two-way ANOVA, followed by post hoc Fisher’s LSD tests. n = 7–12. * p < 0.05 vs. Chow-PBS; ** p < 0.01 vs. Chow-PBS; *** p < 0.001 vs. Chow-PBS; **** p < 0.0001 vs. Chow-PBS.