Table 1.
Weight parameters and left ventricular function of sham-operated and failing hearts.
| Sham-Operated | Heart Failure | |
|---|---|---|
| BW (g) | 519 ± 22 | 510 ± 26 |
| HW (mg) | 1.40 ± 0.08 | 1.63 ± 0.09 |
| LW (mg) | 1.52 ± 0.05 | 3.78 ± 0.65 * |
| HW/BW (mg/g) | 2.69 ± 0.08 | 3.23 ± 0.24 * |
| LW/BW (mg/g) | 2.94 ± 0.08 | 7.53 ± 1.33 * |
| LVDevP (mm Hg) | 116 ± 5 | 87 ± 5 * |
| LVEDP (mm Hg) | 9.0 ± 1.5 | 32.1 ± 4.3 * |
| +(dP/dt)max (mm Hg/s) | 6349 ± 400 | 3990 ± 306 * |
| −(dP/dt)max (mm Hg/s) | 5613 ± 589 | 3127 ± 354 * |
| HR (beats/min) | 333 ± 13 | 318 ± 9 |
BW, body weight; HW, heart weight; LW, lungs weight; HW/BW, relative heart weight; LW/BW, relative lungs weight; LVDP, left ventricular developed pressure; LVEDP, left ventricular end-diastolic pressure; +(dP/dt)max, maximum rate of pressure development; -(dP/dt)max, maximum rate of pressure decline; HR, heart rate. Data are presented as means SEM, n = 6–9 per group. * p < 0.05 vs. Sham.