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Short term (72 h) effect of selumetinib and BEZ235 on the cell viability (SRB assay). (a,b) Selumetinib was more effective on BRAF mutant cell lines (blue) than on BRAF + PI3K/PTEN mutant cell lines (green). After treatment with BEZ235, sensitivity difference was not detected in the mutational groups. (c,d) Average cell viability upon treatment with selumetinib or BEZ235 in the two mutational groups. Data is shown as mean ± SEM from at least three independent experiments.
