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. 2020 Oct 16;21(20):7649. doi: 10.3390/ijms21207649

Figure 2.

Figure 2

Colony formation inhibitory effect of selumetinib and BEZ235 for 10 days. (a,b) BRAF mutant (blue marked) cell lines were more sensitive to selumetinib than the BRAF + PI3K/PTEN mutant (green) cells; on the other hand, BEZ235 inhibited the cell lines with BRAF + PI3K/PTEN mutation more effectively than the BRAF mutant cell lines. (c,d) Average clonogenic potential in the mutational groups after treatment with selumetinib or BEZ235. Data is shown the mean ± SEM from at least three independent experiments.