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Mutational status of the cell lines (based on CCLE, COSMIC, and ExPASy databases).
| Cell Line | Tissue | BRAF | PI3K/PTEN | RAS |
|---|---|---|---|---|
| A375 | melanoma | V600E | wild type | wild type |
| WM35 | melanoma | V600E | wild type | wild type |
| CRL5885 | lung | G466V | wild type | wild type |
| SKMEL28 | melanoma | V600E | PTEN T167A | wild type |
| A2058 | melanoma | V600E | PTEN null | wild type |
| WM239 | melanoma | V600D | PTEN null | wild type |
| HT29 | colon | V600E | PI3KCA P449T | wild type |
| SW1417 | colon | V600E | delPI3KR1 [70] | wild type |
