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. 2020 Oct 14;21(20):7585. doi: 10.3390/ijms21207585

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relationships between microgravity and cancers. (A). Wilcoxon rank-sum test results. (B). Pathway enrichment analysis for 115 DE genes. The length of blue and red bar represents the number of genes and −log10(p-value), respectively. The pink bar represents p-value = 0.05. (C). Boxplots of the expression of six genes (HLA-DPA1, HLA-DQA1, HLA-DPB1, HLA-DMB, CXCL12 and TNFSF13) in rectum adenocarcinoma (READ) samples and microgravity samples. (D). Intestinal immune network for IgA production pathway. The green box represents the downregulated gene enriched in the pathway.