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. 2020 Oct 19;21(20):7739. doi: 10.3390/ijms21207739
AD Alzheimer’s disease
ADAM A disintegrin and metalloprotease
AICD APP intracellular domain
APP β-amyloid precursor protein
Aph-1 Anterior pharynx-defective 1
Asn Asparagine
β-amyloid
BACE1 β-site APP cleaving enzyme-1
FDG Fluoro-2-deoxy-D-glucose
GalNAc N-acetylgalactosamine
GFAT Glutamine-fructose-6-phosphate amidotransferase
GlcNAc N-acetylglucosamine
GLUT Glucose transporter
GnT-III β1,4-N-acetylglucosaminyltransferase III
HBP Hexosamine biosynthetic pathway
hAPP human APP
LLO Lipid-linked oligosaccharide
MAP Microtubule-associated protein
Mgat3−/− GnT-III-deficient
mOGT Mitochondrial OGT
ncOGT Nucleocytoplasmic OGT
NFTs Neurofibrillary tangles
NICD Notch intracellular domain
OGA O-GlcNAcase
OGA-L OGA Large
OGA-S OGA short
O-GlcNAcylation O-linked β-N-acetylglucosaminylation
OGT O-GlcNAc transferase
OST Oligosaccharyltransferase
Pen-2 Presenilin enhancer 2
PET Positron emission tomography
PSEN Presenilin
PTMs Post-translational modifications
ROS Reactive oxygen species
Ser Serine
sOGT short OGT
TCA Tricarboxylic acid
Thr Threonine
T2DM Type II diabetes mellitus
UDP-GlcNAc Uridine 5′-diphospho-N-acetylglucosamine
3 × Tg-AD Triple transgenic murine model of AD