Figure 1.
Extracellular/intracellular network analysis within the damaged tissue (string-db.org platform) for protein–protein interactions (PPIs). The proteins related to stroke pathophysiology are clustered and PPIs are defined. This map is difficult to use for the design of further experiments since the interference with any node will apply to every edge at the same time, an atypical phenomenon in biological systems. The map is based on a critical analysis of recent literature (see Table 1 for selected experimental studies). The database query with 38 proteins showed 203 edges with an average node degree of 10.7 (expected number of edges 35, average local clustering coefficient 0.575; PPI enrichment p-value < 10−16). For further details, the map is accessible at this link: [37].