Figure 3.

Protein–protein interaction (PPI) maps generated considering the timescale of stroke. Clustering is dependent on time-specific activation, avoiding a direct interaction analysis (presented in Figure 1) and considering the collected literature data and co-expression matrix presented in Figure 2. (A) Alarmins are released and constitutive matrix metalloproteinase 2 (MMP2) and purinergic receptors are promptly activated following stroke. (B) The inflammasome activates the neuro-immune pathway of cytokines, adhesion molecules, protease receptors and inducible MMPs. (C) Leukocytes arrive hours after stroke, act with their enzymes and remain for several days and, while glial activation proceeds, a novel extracellular matrix (NECM) is secreted and reactive gliosis regulates the neurotrophin concentration and receptors.