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. 2020 Oct 11;21(20):7483. doi: 10.3390/ijms21207483

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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IS inhibits the phosphorylation of ERK and p38 MAPK. MC3T3 E1 cells were cultured in an osteogenesis medium with IS at 0, 100, 500, and 1000 μM with or without RSV for 2 h. (A–D) In whole cells, the phosphorylation of ERK1/2 and p38 decreased in a dose-dependent manner with the concentration of IS. At 500 and 1000 μM IS, ERK1/2 and p38 MAPK phosphorylation was significantly suppressed in comparison to the control group. RSV significantly alleviated ERK1/2 phosphorylation at 500 and 1000 μM IS. (E) At 500 μM IS, the expression of ERK1 and p38 genes was significantly reduced compared to their levels in the control group. When RSV is also added, the expression of ERK1 and p38 genes is significantly increased in response to IS treatment at 0 and 500 μM. Data are represented as the mean ± SEM (n = 3). * Indicates differences that were considered significant between the indicated groups (p < 0.05).

IS inhibits the phosphorylation of ERK and p38 MAPK. MC3T3 E1 cells were cultured in an osteogenesis medium with IS at 0, 100, 500, and 1000 μM with or without RSV for 2 h. (A–D) In whole cells, the phosphorylation of ERK1/2 and p38 decreased in a dose-dependent manner with the concentration of IS. At 500 and 1000 μM IS, ERK1/2 and p38 MAPK phosphorylation was significantly suppressed in comparison to the control group. RSV significantly alleviated ERK1/2 phosphorylation at 500 and 1000 μM IS. (E) At 500 μM IS, the expression of ERK1 and p38 genes was significantly reduced compared to their levels in the control group. When RSV is also added, the expression of ERK1 and p38 genes is significantly increased in response to IS treatment at 0 and 500 μM. Data are represented as the mean ± SEM (n = 3). * Indicates differences that were considered significant between the indicated groups (p < 0.05).