Table 2.
Overview of differentially expressed miRNA in gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs).
| Tissues/Cells | miRNAs | Potential Biological Role in GEP-NET | Platform for miRNA Expression Analysis | Internal Control for qPCR | AUC Value_ROC | Study |
|---|---|---|---|---|---|---|
| GEP-NET (79) | Specific site miRNA profiles (see article) | / | qPCR | / | / | [49] |
| GEP-NET subtypes (64) | / | / | Small RNA sequencing; qPCR | U6 | / | [50] |
| Primary pNET (63), metastatic pNET (18), non-metastatic pNET (41) |
miR-21 (↑), miR-10a (↑), miR-106b (↑) |
Correlation with PanNET tumorigenesis | Bioinformatic analysis; qPCR | RNU6B | / | [51] |
| pNETs (6), HC (5) | 28 miRNAs (see article) | / | Bioinformatic analysis from GEO data | / | / | [52] |
| pNET (37) |
miR-3653 (↑), miR-4417 (↓), miR-574-3p (↓), miR-664b-3p (↓) |
/ | Microarray | / | / | [53] |
| pNET (57) |
miR-145-5p, miR-34a-5p, miR-132-3p, miR-183-5p, miR-449a |
Association with cell proliferation | qPCR | / | / | [54] |
| gNETs, NGM | miR-202-3p (↑) | Role in the process of dysplasia and tumor formation | Microarray; qPCR | 5S rRNA | / | [55] |
| Hypergastrinemic patients with autoimmune atrophic gastritis and type 1 gNETs (8), HC (10), AGSGR cells | miR-222 (↑) | Increased migration and actin remodeling | miRNA PCR arrays; qPCR | RNU62 | / | [56] |
| Resected pNET (37), non-neoplastic pancreas (37), primary pNET (2), pNET with liver metastasis (2) |
miR-196a (↑), miR-142-5p (↑) |
Association with aggressive behavior of Pan-NETs | qPCR | U6 |
0.833 (miR-196a) 0.747 (miR-27b) |
[57] |
| GEP-NET before and after SSA therapy (8) |
let-7c-5p (↑), mir-24-3p (↑), mir-215-5p (↑), mir- 10a-3p (↓), mir-185-3p (↓), mir-339-5p (↓), mir-371a-5p (↓), mir-4436b- 5p (↓), mir-4653-3p (↓), mir-4793-3p (↓), mir-619-5p (↓), mir-1226-3p (↓), mir-3137 (↓), mir-4455 (↓), mir-4656 (↓) |
/ | Microarray; qPCR | RNU6-2_11 | / | [58] |
| MIN6 cells | miR-17 (↑) | Role in glucose-induced β cell proliferation | qPCR | U6 | / | [59] |
Tissues isolated from patients are shown in parentheses. Table 2 footnotes: pNET = pancreas neuroendocrine tumor; HC = healthy controls; gNET = gastric neuroendocrine tumor; NGM= non-tumor gastric mucosa; GEP-NET = gastro-entero-pancreatic neuroendocrine tumor.