Table 4.
Overview of c-miRNAs as candidate biomarkers in sporadic non-MEN1 associated tumors.
| Biological Fluid | Study Population | c-miRNAs | Platform for miRNA Expression Analysis | Reference Genes for qPCR | AUC Value ROC | Study |
|---|---|---|---|---|---|---|
| Serum | Untreated siNET (21), SSA-treated siNET (21), HC (9) |
miR-96 (↑), miR-182 (↑), miR-183 (↑) mIR-196a (↑), miR-200a (↑), miR-31 (↓), miR-129-5p (↓), miR-133a (↓), miR-215 (↓), miR-96 (↓), miR-182 (↓), miR-183 (↓), mIR-196a (↓), miR-200a (↓) |
qPCR | miR-16 | / | [80] |
| Plasma | Localized pancreatic cancer (15), HC (15) |
miR-196a (↑), miR-1246 (↑) |
qPCR | cel-miR-54 | / | [81] |
| Serum | siNET (32), HC (25) | miR-7-5p (↑) | qPCR | cel-miR-54 | 0.839 (miR-7-5p) | [82] |
| Serum | Pituitary tumor (36), HC (8) | miR-16 (↓) | qPCR | / | / | [83] |
| Plasma | Different types of PA (45), HC (2) | miR-143-3p (↓) | NGS, qPCR | / | 0.79 (miR-143-3p) | [84] |
| Serum | GH-PA (6), HC (6) |
miR-423-5p (↓), miR-320a (↓) |
miRScanTM Panel Chip qPCR | QB-spikein-2 | / | [85] |
Enrolled population is shown in parentheses. Table 4 footnotes: siNET = small intestine neuroendocrine tumor; SSA = somatostatin analogue; HC = healthy control; PA = pituitary adenoma; GH-PA = growth hormone-secreting pituitary adenoma.