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Role of the ECM in modulating the tumor immune microenvironment: Matrix remodeling shapes the inflamed immune microenvironment. “Inflamed” tumor releases the antigens that are used for antigen presentation. The ECM components are processed by the metalloproteases to release matrikines (versikine) which in turn regulate the priming and activation of T cells. ECM also serves as a scaffold for T cell migration by haptotaxis.
