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Sequence alignment of integrases from HIV-1 and HIV-2. Integrase from HIV-1 of pNL4-3 (IN_HIV-1) and two integrase species from two HIV-2 isolates (IN-HIV-2_TRA and IN-HIV-2_ALL) are aligned. Residues conserved in at least two sequences are outlined in dark grey, similar residues are in light grey. The three structural domains (NTD, CCD, and CTD) are indicated according to Figure 1A.
