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. 2020 Oct 21;12(10):1202. doi: 10.3390/v12101202

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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3D model of the platform for association of IN-CTD with mLysRS. Left: The structural model shows a dimer of human LysRS in association with a monomer of the CTD of integrase from HIV-1. The two monomers of LysRS (3BJU) are in cyan and green, the two tRNA molecules in orange, the monomer of IN-CTD (5U1C) in magenta. The residues that build the platform for the assembly of the complex are represented by spheres. Docking of the two tRNA molecules was performed using the crystal structure of yeast aspartyl-tRNA synthetase complexed with two tRNA molecules (1ASY). Right: Zoom of the IN-CTD:LysRS interaction platform. Residues from the platform are labeled and colored according to the main chains.