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. 2020 Oct 21;21(20):7794. doi: 10.3390/ijms21207794

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Platelet and leukocyte interactions in innate immunity cell interactions. Platelets interact with neutrophils, monocytes, and ultimately as well with MΦs, modulating and increasing their effector functions. These platelet-leukocyte interactions result in inflammatory contributions through different mechanisms, including NETosis [67]. Abbreviations: MPO: myeloperoxidase, ROS: reactive oxygen species, TF: tissue factor, NET: neutrophil extracellular traps, NF-κB: nuclear factor kappa B, MΦ: macrophage.