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. 2020 Oct 21;21(20):7794. doi: 10.3390/ijms21207794

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustration of the multifaceted 5-HT responses following inflammatory PRP-platelet activation. After platelet activation, platelets release their granules, including 5-HT from dense granules, inciting a wide range of differential effects on various immune, endothelial, and smooth muscle cells. Abbreviations: SMC: smooth muscle cell, EC: endothelial cell, Treg: regular T lymphocyte, MΦ: macrophage, DC: dendritic cell, IL: interleukin, IFN-γ: interferon gamma. Modified and adapted from Everts et al. and Herr et al. [9,69].