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. 2020 Oct 14;21(20):7578. doi: 10.3390/ijms21207578

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene expression of the main enzymes/transporters of the 5-HT and KYN pathways in rat fetal organs. Log2 fold change (FC) of gene expression at GD 21 compared to GD 18 is shown for the fetal brain (A), intestine (B), liver (C), heart (D), and lungs (E). Red color indicates upregulation, whereas green color indicates downregulation. Data are presented as the median with IQR; n = 5 for each gestational age. Statistical analysis of gestational age changes in the mRNA expression of target genes was evaluated using the non-parametric Mann–Whitney test; * (p ≤ 0.05) and ** (p ≤ 0.01). N.D., not detected.