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. 2020 Oct 17;12(10):983. doi: 10.3390/pharmaceutics12100983

Table 2.

Recent studies on sodium alginate-based electrospun nanofibers (SA-eNFs) used as wound dressings.

Biopolymer/
Copolymer		 Bioactive Agent Type of Electrospinning Main Findings References
SA/Polyethylene
oxide (PEO) 		Gabapentin/Acetamino-phen Double-layered Blend electrospinning
  • -

    Bi-layered formulation: eNFs loaded with gabapentin, where the contact layer consists of PEO and second layer of SA; acetaminophen was added in the eNFs design for synergizing the analgesic effect;

  • -

    Drug release from the coating layer exhibited a first-order kinetic model, whereas the release from the second layer a Hixson–Crowell kinetic model;

  • -

    Potential application for decreasing pain scores with a reduction of side effects in burn patients.

 [120]
SA/PVA - Blend electrospinning/three-dimensional (3D) printing
  • -

    The double-layered carriers with eNFs as the surface layer proved decreased adhesiveness and increased physical durability compared to the solvent cast (SC) film;

  • -

    Bi-layered SC/eNFs carrier showed the most proper physical architecture for proliferation and cell adhesion due to the highest value of cell viability measured in comparison with bi-layered SC/3D carrier;

  • -

    High potential for the state of the art of technical approach with inkjet printing-electrospinning in fabrication of bioactive wound patches.

 [121]
SA/Poly lactic acid (PLA)/polyvinyl alcohol (PVA) - Blend electrospinning
  • -

    In vitro studies demonstrated that PLA/PVA/SA nanofiber scaffold could offer proper anchor for the proliferation of rat fibroblasts (L929);

  • -

    In vivo biological assessment was performed on skin defects rat models in which the formulated nonofibrous membranes improved wound healing with a reduction of the inflammatory reaction during incipient wound healing compared to commercially available gauzes.

 [122]
SA/PVA-Triton-Chitosan (CS) Dex-Panthenol Blend electrospinning
  • -

    Drug release of dexpanthenol followed the Fickian diffusion mechanism with the model of Korsmeyer-Peppas.

  • -

    Cell culture and MTT analysis revealed that dexpanthenol-loaded SA/PVA/Triton-CS eNFs were non-toxic towards fibroblast cells and improved the cellular attachment.

  • -

    It was indicated that SA/PVA/Triton-CS eNFs can be utilized for various applications in tissue engineering.

 [84]