DXT
/Polyurethane (PU)
|
Ciprofloxacin hydro
chloride (Cip)
|
Blend elctrospinning |
-
-
Cip addition decreased the size and narrowed down the partition of eNFs diameters, which was translated into a reduction in solution viscosity;
-
-
DXT inclusion into the PU enhanced the cell adherence and viability;
-
-
The DXT-PU-Cip eNFs showed good antibacterial potential towards both Gram-positive and Gram-negative bacteria;
-
-
A potential ideal antibacterial biomaterial for wound dressing applications.
|
[179] |
DXT-cellulose acetate (CA)
/PCL
|
Tetracycline hydro-
chloride (TC)
|
Blend elctrospinning |
-
-
TC incorporation improved blood clotting, enhanced cell proliferation, cell attachment and the antimicrobial activity of DXT-CA-TC/PCL eNFs;
-
-
After fibroblast cells were seeded on the eNFs scaffolds, it was indicated a strongly increased cell attachment and proliferation; also, DXT-CA-TC/PCL eNFs exhibited high antibacterial activity, thanks to TC presence;
-
-
DXT-CA-TC/PCL eNFs present suitable properties for wound dressing development and skin engineering applications;
|
[181] |
|
DXT/PVA
|
Ciprofloxacin (Cip)
|
Emulsion
electrospinning |
-
-
DXT/PVA ratio blend was optimized and eNFs were stabilized by thermal treatment at 120 °C regarding disintegration in water;
-
-
SEM analysis correlated with DSC confirms the core-shell structure of the eNFs, while DSC indicated the DXT-PVA interaction; The in vitro release study showed a Cip sustain release, controlled by the DXT content which can hapen by diffusion within the delivery system;
-
-
DXT/PVA-Cip eNFs can be formulated by a green method and are auspicious eco-friendly drug delivery systems;
|
[106] |
|
DXT/PU
|
Curcumin (Cr)
|
Blend elctrospinning |
-
-
DXT incorporation demonstrated increment in percentage sorption values, vapour transmission rate, biodegradability, and hydrophilicity;
-
-
DXT induces enhanced hemostasis potential and high degree of platelet adhesion essential for promoting wound healing;
-
-
20 wt% DXT loaded eNFs (20DXT/PU) exhibited high attachment, cell proliferation and cytoviability against 3T3 fibroblasts; Cr loaded 20DXT/PU showed synergic antibacterial effect against Gram-positive bacteria and a pH-controlled drug release potency so it is promising wound dressing material.
|
[182] |
