Table 1.
Significant functional enrichment predicted by Ingenuity Pathway Analysis.
| Category | Predicted Result | Upregulated Group | z-Score 1 | FDR 2 |
|---|---|---|---|---|
| K20-only vs. K5/6-only group | ||||
| Upstream | RABL6 | K20-only | 2.530 | 5.9 × 10−4 |
| Upstream | ID2 | K20-only | 2.208 | 5.5 × 10−3 |
| Upstream | EFNA4 | K20-only | 2.449 | 1.9 × 10−2 |
| Upstream | PPARGC1A | K20-only | 3.125 | 1.9 × 10−2 |
| Upstream | EFNA3 | K20-only | 2.449 | 1.9 × 10−2 |
| Upstream | EFNA5 | K20-only | 2.449 | 2.2 × 10−2 |
| Upstream | TP53 | K5/6-only | 2.752 | 1.0 × 10−7 |
| Upstream | TP63 | K5/6-only | 2.213 | 3.3 × 10−6 |
| Upstream | TGFB1 | K5/6-only | 4.169 | 2.3 × 10−5 |
| Upstream | PGR | K5/6-only | 2.288 | 8.8 × 10−5 |
| Upstream | CDKN2A | K5/6-only | 2.701 | 2.8 × 10−4 |
| Upstream | KDM5B | K5/6-only | 3.143 | 3.3 × 10−4 |
| Upstream | BRCA1 | K5/6-only | 2.063 | 3.7 × 10−4 |
| Upstream | RAF1 | K5/6-only | 3.385 | 3.7 × 10−4 |
| Upstream | CDKN1A | K5/6-only | 2.408 | 4.6 × 10−4 |
| Upstream | RB1 | K5/6-only | 2.134 | 6.8 × 10−4 |
| Upstream | SMARCA4 | K5/6-only | 2.959 | 7.6 × 10−4 |
| Upstream | NUPR1 | K5/6-only | 3.413 | 8.5 × 10−4 |
| Upstream | IKBKB | K5/6-only | 2.016 | 1.7 × 10−3 |
| Upstream | EGF | K5/6-only | 2.089 | 2.0 × 10−3 |
| Upstream | HIF1A | K5/6-only | 2.059 | 3.2 × 10−3 |
| Upstream | TGF beta | K5/6-only | 2.288 | 3.4 × 10−3 |
| Upstream | FSHB | K5/6-only | 2.190 | 6.4 × 10−3 |
| Upstream | FGF2 | K5/6-only | 3.083 | 8.0 × 10−3 |
| Upstream | JAG1 | K5/6-only | 2.646 | 8.1 × 10−3 |
| Upstream | PDGF BB | K5/6-only | 2.652 | 8.9 × 10−3 |
| Upstream | IGF1 | K5/6-only | 2.083 | 9.8 × 10−3 |
| Upstream | CG | K5/6-only | 2.332 | 1.2 × 10−2 |
| Upstream | JUN | K5/6-only | 2.502 | 1.3 × 10−2 |
| Upstream | BNIP3L | K5/6-only | 2.630 | 1.9 × 10−2 |
| Upstream | CTNNB1 | K5/6-only | 2.630 | 2.3 × 10−2 |
| Upstream | Calcineurin A | K5/6-only | 2.200 | 2.9 × 10−2 |
| Upstream | EDN1 | K5/6-only | 2.439 | 3.6 × 10−2 |
| Upstream | ERK1/2 | K5/6-only | 2.163 | 3.7 × 10−2 |
| Upstream | TGFB3 | K5/6-only | 2.926 | 3.8 × 10−2 |
| Upstream | STAT3 | K5/6-only | 2.209 | 3.8 × 10−2 |
| Disease/function | Endocrine gland tumor | K20-only | 2.213 | 3.1 × 10−8 |
| Disease/function | Congenital anomaly of digit | K20-only | 2.000 | 7.3 × 10−3 |
| Disease/function | Invasion of tumor cell lines | K5/6-only | 2.069 | 1.3 × 10−5 |
| Disease/function | Migration of cells | K5/6-only | 2.102 | 3.4 × 10−5 |
| Disease/function | Cell movement | K5/6-only | 2.591 | 4.5 × 10−5 |
| Disease/function | Adhesion of tumor cell lines | K5/6-only | 2.481 | 7.4 × 10−4 |
| Disease/function | Binding of tumor cell lines | K5/6-only | 2.444 | 8.7 × 10−4 |
| Disease/function | Attachment of cells | K5/6-only | 2.040 | 1.5 × 10−3 |
| Disease/function | Invasion of breast cancer cell lines | K5/6-only | 2.015 | 1.5 × 10−3 |
| Disease/function | Cell movement of breast cancer cell lines | K5/6-only | 2.014 | 4.1 × 10−3 |
| Disease/function | Apoptosis of prostate cancer cell lines | K5/6-only | 3.467 | 5.9 × 10−3 |
| Disease/function | Formation of gamma H2AX nuclear focus | K5/6-only | 2.345 | 6.1 × 10−3 |
| Disease/function | Cell movement of endothelial cells | K5/6-only | 2.190 | 6.3 × 10−3 |
| Disease/function | Apoptosis of cancer cells | K5/6-only | 2.420 | 7.0 × 10−3 |
| Disease/function | Necrosis of tumor | K5/6-only | 2.495 | 7.7 × 10−3 |
| Disease/function | Necrosis of prostate cancer cell lines | K5/6-only | 3.223 | 8.2 × 10−3 |
| K20-only vs. double-high group | ||||
| Upstream | ERBB2 | K20-only | 3.284 | 7.2 × 10−4 |
| Upstream | EP400 | K20-only | 2.449 | 1.8 × 10−3 |
| Upstream | E2f | K20-only | 2.199 | 2.8 × 10−3 |
| Upstream | RABL6 | K20-only | 3.000 | 5.6 × 10−3 |
| Upstream | ID2 | K20-only | 2.563 | 5.6 × 10−3 |
| Upstream | ID3 | K20-only | 2.157 | 2.1 × 10−2 |
| Upstream | E2F3 | K20-only | 2.534 | 2.1 × 10−2 |
| Upstream | MITF | K20-only | 2.575 | 3.0 × 10−2 |
| Upstream | SREBF2 | K20-only | 2.557 | 4.7 × 10−2 |
| Upstream | TP53 | Double-high | 3.069 | 2.8 × 10−8 |
| Upstream | CDKN2A | Double-high | 4.097 | 3.7 × 10−4 |
| Upstream | CDKN1A | Double-high | 2.729 | 4.5 × 10−4 |
| Upstream | MLXIPL | Double-high | 3.592 | 1.4 × 10−3 |
| Upstream | OGA | Double-high | 3.272 | 2.5 × 10−3 |
| Upstream | MYCN | Double-high | 2.385 | 8.1 × 10−3 |
| Disease/function | DNA replication | K20-only | 2.159 | 8.8 × 10−5 |
| Disease/function | Genitourinary adenocarcinoma | K20-only | 2.177 | 1.0 × 10−4 |
| Disease/function | Proliferation of connective tissue cells | K20-only | 3.115 | 4.2 × 10−4 |
| Disease/function | Growth of connective tissue | K20-only | 2.790 | 5.5 × 10−4 |
| Disease/function | Cell proliferation of breast cancer cell lines | K20-only | 2.032 | 2.6 × 10−3 |
| Disease/function | Advanced malignant solid tumor | K20-only | 2.228 | 3.6 × 10−3 |
| Disease/function | Growth of organism | K20-only | 2.299 | 6.0 × 10−3 |
| Disease/function | Advanced lung cancer | K20-only | 2.578 | 6.4 × 10−3 |
| Disease/function | Cell cycle progression of tumor cell lines | K20-only | 2.395 | 1.1 × 10−2 |
| Disease/function | Visceral metastasis | K20-only | 2.594 | 1.3 × 10−2 |
| Disease/function | Metastatic solid tumor | K20-only | 2.228 | 1.3 × 10−2 |
| Disease/function | Advanced extracranial solid tumor | K20-only | 2.576 | 1.8 × 10−2 |
| Disease/function | Cell death of breast cancer cell lines | Double-high | 2.359 | 2.7 × 10−5 |
| Disease/function | Cell death of tumor cell lines | Double-high | 3.092 | 4.4 × 10−5 |
| Disease/function | Apoptosis | Double-high | 2.128 | 2.1 × 10−4 |
| Disease/function | Gastrointestinal tract cancer | Double-high | 2.000 | 1.1 × 10−3 |
| Disease/function | Senescence of cells | Double-high | 2.104 | 1.1 × 10−3 |
| Disease/function | Cell death of lung cancer cell lines | Double-high | 2.444 | 3.7× 10−3 |
| Disease/function | Colon tumor | Double-high | 2.364 | 7.1 × 10−3 |
| Disease/function | Proliferation of hematopoietic progenitor cells | Double-high | 2.005 | 1.6 × 10−2 |
| Disease/function | Colorectal tumor | Double-high | 2.078 | 1.6 × 10−2 |
| Disease/function | Cytostasis of tumor cell lines | Double-high | 2.145 | 1.8 × 10−2 |
| K5/6-only vs. double-high group | ||||
| Upstream | EPAS1 | K5/6-only | 2.000 | 3.9 × 10−2 |
| Disease/function | NA | NA | NA | NA |
| K20-only vs. double-low group | ||||
| Upstream | ID3 | K20-only | 2.213 | 1.2 × 10−2 |
| Upstream | MYC | K20-only | 2.299 | 1.3 × 10−2 |
| Upstream | LLGL2 | K20-only | 2.000 | 4.4 × 10−2 |
| Upstream | ERBB3 | K20-only | 2.588 | 4.7 × 10−2 |
| Disease/function | Genitourinary tumor | K20-only | 2.017 | 2.1 × 10−3 |
| Disease/function | Malignant genitourinary solid tumor | K20-only | 2.139 | 2.1 × 10−3 |
| Disease/function | Adenocarcinoma | K20-only | 2.204 | 3.2 × 10−3 |
| Disease/function | Anogenital cancer | K20-only | 2.144 | 3.9 × 10−3 |
| Disease/function | Incidence of tumor | K20-only | 2.257 | 7.0 × 10−3 |
| Disease/function | Carcinoma | K20-only | 2.292 | 7.8 × 10−3 |
| Disease/function | Extracranial solid tumor | K20-only | 2.697 | 1.4 × 10−2 |
| Disease/function | Malignant solid tumor | K20-only | 2.026 | 2.3 × 10−2 |
| Disease/function | Epithelial–mesenchymal transition of breast cell lines | K20-only | 2.108 | 2.8 × 10−2 |
| K5/6-only vs. double-low group | ||||
| Upstream | TP53 | K5/6-only | 2.086 | 1.8 × 10−4 |
| Disease/function | NA | NA | NA | NA |
1 z-score indicates an activation level of the predicted result based on the DEG fold change and its agreement with the result. 2 FDR, false discovery rate (Benjamini Hochberg).