Table 1.
List of human tetraspanin superfamily members. Data were acquired from the UniProt database (UniProt Consortium. (2019). UniProt: A worldwide hub of protein knowledge. Nucleic acids research, 47(D1), D506-D515).
| Protein Name | Alternative Name (s) | Gene Name |
|---|---|---|
| Tetraspanin-1 | Tetraspan NET-1 (neuroepithelial cell-transforming gene 1 protein), Tetraspanin TM4-C | TSPAN1 |
| Tetraspanin-2 | Tetraspan NET-3 | TSPAN2 |
| Tetraspanin-3 | Tetraspanin TM4-A, Transmembrane 4 superfamily member 8 | TSPAN3 |
| Tetraspanin-4 | Novel antigen 2 (NAG-2), Transmembrane 4 superfamily member 7 | TSPAN4 |
| Tetraspanin-5 | Tetraspan NET-4, Transmembrane 4 superfamily member 9 | TSPAN5 |
| Tetraspanin-6 | A15 homologue, Putative NF-kappa-B-activating protein 321, T245 protein, Tetraspanin TM4-D, Transmembrane 4 superfamily member 6 | TSPAN6 |
| Tetraspanin-7 | Cell surface glycoprotein A15, Membrane component chromosome X surface marker 1, T-cell acute lymphoblastic leukemia-associated antigen 1 (TALLA-1), Transmembrane 4 superfamily member 2, CD231 | TSPAN7 |
| Tetraspanin-8 | Transmembrane 4 superfamily member 3, Tumor-associated antigen CO-029 | TSPAN8 |
| Tetraspanin-9 | Tetraspan NET-5 | TSPAN9 |
| Tetraspanin-10 | OCULOSPANIN | TSPAN10 |
| Tetraspanin-11 | - | TSPAN11 |
| Tetraspanin-12 | Tetraspan NET-2, Transmembrane 4 superfamily member 12 | TSPAN12 |
| Tetraspanin-13 | Tetraspan NET-6, Transmembrane 4 superfamily member 13 | TSPAN13 |
| Tetraspanin-14 | DC-TM4F2, Transmembrane 4 superfamily member 14 | TSPAN14 |
| Tetraspanin-15 | Tetraspan NET-7, Transmembrane 4 superfamily member 15 | TSPAN15 |
| Tetraspanin-16 | Tetraspanin TM4-B, Transmembrane 4 superfamily member 16 | TSPAN16 |
| Tetraspanin-17 | F-box only protein 23, Tetraspan protein SB134, Transmembrane 4 superfamily member 17 | TSPAN17 |
| Tetraspanin-18 | - | TSPAN18 |
| Putative tetraspanin-19 | - | TSPAN19 |
| Uroplakin-1b (UP1b) | Tetraspanin-20 (Tspan-20) | UPK1B |
| Uroplakin-1a (UP1a, UPKa) | Tetraspanin-21 (Tspan-21) | UPK1A |
| Peripherin-2 | Retinal degeneration slow protein, Tetraspanin-22 (Tspan-22) | PRPH2 |
| Rod outer segment membrane protein 1 (ROSP1) | Tetraspanin-23 (Tspan-23) | ROM1 |
| CD151 antigen | CD151, GP27, Membrane glycoprotein SFA-1, Platelet-endothelial tetraspan antigen 3 (PETA-3), Tetraspanin-24 (Tspan-24) | CD151 |
| Leucocyte surface antigen CD53 | CD53, Cell surface glycoprotein CD53, Tetraspanin-25 (Tspan-25) | CD53 |
| Leucocyte antigen CD37 | CD37, Tetraspanin-26 (Tspan-26) | CD37 |
| CD82 antigen | CD82, C33 antigen, IA4, Inducible membrane protein R2, Metastasis suppressor Kangai-1, Suppressor of tumorigenicity 6 protein, Tetraspanin-27 (Tspan-27) | CD82 |
| CD81 antigen | CD81, 26 kDa cell surface protein TAPA1, Tetraspanin-28 (Tspan-28), Target of the antiproliferative antibody 1 | CD81 |
| CD9 antigen | CD9, 5H9 antigen, Cell growth-inhibiting gene 2 protein, Leukocyte antigen MIC3, Motility-related protein (MRP-1), p24, Tetraspanin-29 (Tspan-29) | CD9 |
| CD63 antigen | CD63, Granulophysin, Lysosomal-associated membrane protein 3 (LAMP-3), Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30 (Tspan-30) | CD63 |
| Tetraspanin-31 (Tspan-31) | Sarcoma-amplified sequence | TSPAN31 |
| Tetraspanin-32 (Tspan-32) | Protein Phemx | TSPAN32 |
| Tetraspanin-33 (Tspan-33) | Penumbra (hPen), Proerythroblast new membrane | TSPAN33 |