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. 2020 Oct 19;9(10):2321. doi: 10.3390/cells9102321

Figure 2.

Figure 2

HDACs gene expression changes during activation of HSCs. Liver injury induces the activation of HSCs, which is characterized by increased production of ECM components and inflammatory mediators, as well as by increased proliferation and chemotaxis. During HSC activation several HDACs are differentially expressed, and their activity contributes to the expression of antifibrogenic as well as profibrogenic genes. HDAC inhibitors such as VPA, TSA, SAHA, and MC1568 inhibit the transdifferentiation of quiescent HSCs into myofibroblast-like fibrogenic HSCs.