FIGURE 5.

Correlations between quantitative MRI parameters and FRDA patients' disease characteristics as well as with patient age. (a) Correlation coefficients (ρ, first row) and p‐values (p, second row) for correlations between mean volumes of interest (VOIs) values for the different imaging contrasts (susceptibility $\chi$, relaxation rates R ₁ and R ₂, diffusion fractional anisotropy FA) and age at onset (first column), patient age (second column), GAA1 repeats (third column), and GAA2 repeats (fourth column). White stars indicate significant correlations, green stars indicate that for this contrast/VOI combination, additionally significant differences between patients and healthy controls have been found (see Figure 2). Correlations for contrast/VOI combinations, for which no correlation with patient age was found, are marked with a black circle. (b) Scatterplots for the contrasts and VOIs for which significant correlations with disease characteristic, but not with patient age were found [Color figure can be viewed at wileyonlinelibrary.com]