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. 2020 Sep 28;21(9):498–504. doi: 10.1111/1751-2980.12923

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© 2020 The Authors. Journal of Digestive Diseases published by Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A, White light endoscopy; B, Chromoendoscopy with indigo carmine; C, Narrow‐band imaging‐magnifying endoscopy does not show any lesions near the anal verge in the lower rectum; D, Autofluorescence endoscopy using 5‐aminolevulinic acid showing irregularly shaped areas with strong green fluorescent signals (arrows); E, Histopathology showing high‐grade dysplasia characterized by cellular and structural dysplasia (HE stain, ×200); F, Immunohistology showing p53‐positive epithelial cells (×200)