Figure 3.

Microenvironment in breast cancer (BCa). The tumor microenvironment consists of numerous cell types like fibroblasts, myofibroblasts, mesenchymal stem cells (MSCs), cancer-associated fibroblasts (CAFs), adipocytes, endothelial cells (ECs), and immune cells like T-cells, B-cells, natural killer (NK) cells, macrophages, tumor associated macrophages (TAMs), neutrophils, myeloid-derived suppressor cells, cancer stem cells (CSCs), and tumor cells. The base of all interactions forms the extracellular matrix (ECM).